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Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
Keratin 5-Cre-driven deletion of
Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang
Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 305-317 doi: 10.1007/s11684-019-0722-8
Keywords: acne inversa mouse model interleukin 1 family member 6 small proline rich protein 2D key inflammatorycytokine
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea
Keywords: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
Frontiers of Medicine doi: 10.1007/s11684-023-1044-4
Keywords: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 292-301 doi: 10.1007/s11684-020-0806-5
Keywords: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
Inflammation and liver tumorigenesis
Beicheng Sun, Michael Karin
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 242-254 doi: 10.1007/s11684-013-0256-4
Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.
Keywords: hepatocellular carcinoma hepatitis cytokine stem cell miRNA
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy
Keywords: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 73-83 doi: 10.15302/J-FASE-2015044
Keywords: chicken SOCS1a SOCS1b growth hormone prolactin
Management of cytokine release syndrome related to CAR-T cell therapy
Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 610-617 doi: 10.1007/s11684-019-0714-8
Keywords: chimeric antigen receptor T cell cytokine release syndrome tocilizumab
Yan Zhao, Chengcheng Zhang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
Engineering 2022, Volume 17, Issue 10, Pages 170-182 doi: 10.1016/j.eng.2020.09.016
•Some specific genes may account for the anti-inflammatory and immunoregulation of of the phylogenetic tree and strain type L. fermentum CECT5716 were selected and their anti-inflammatoryThe anti-inflammatory mechanisms of L. fermentum FXJCJ61 and CECT5716 were related to the inhibitionComparative genomic analysis of these strains identified candidate genes that may contribute to the anti-inflammatory
Keywords: Lactobacillus fermentum Ulcerative colitis Anti-inflammation Phylogenetic analysis Comparative genomic analysis
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 319-332 doi: 10.1007/s11684-017-0569-9
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.
Keywords: diabetic nephropathy immune inflammatory response epithelial–mesenchymal transition apoptosis mitochondrial
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie
Strategic Study of CAE 2015, Volume 17, Issue 6, Pages 4-7
Keywords: levonorgestrel Intrauterine system insulin-like growth factor-1 pelvic inflammatory disease
NEW ZEALAND DAIRY FARM SYSTEMS AND KEY ENVIRONMENTAL EFFECTS
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 1,
Bioaerosol: A Key Vessel between Environment and Health
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-021-1422-6
Title Author Date Type Operation
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article
Keratin 5-Cre-driven deletion of
Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang
Journal Article
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Journal Article
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
Journal Article
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Journal Article
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
Journal Article
Management of cytokine release syndrome related to CAR-T cell therapy
Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He
Journal Article
Phylogenetic and Comparative Genomic Analysis of Lactobacillus fermentum Strains and the Key GenesRelated to Their Intestinal Anti-inflammatory Effects
Yan Zhao, Chengcheng Zhang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
Journal Article
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Journal Article
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory
Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie
Journal Article